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View 4 excerpts, cites background. Psychological medicine. Schizophrenia Research. Comprehensive psychiatry. On the positive and negative syndrome scale and remission in schizophrenia. Computer Science, Medicine. Highly Influenced. View 4 excerpts, cites methods and background.

Significance of the positive-negative distinction in schizophrenia. Assessing positive and negative symptoms in outpatients with schizophrenia and mood disorders. The Journal of nervous and mental disease. View 2 excerpts. Assessment of negative and positive symptoms in schizophrenia. View 2 excerpts, references methods and background.

Positive and negative subtypes in acute schizophrenia. View 5 excerpts, references background and results. Positive and negative syndromes in schizophrenia as a function of chronicity. Acta psychiatrica Scandinavica. Significance of positive and negative syndromes in chronic schizophrenia. The British journal of psychiatry : the journal of mental science. View 2 excerpts, references background. In many situations, it will be of relevance for both researchers and clinicians to address multiple additional dimensions, including psychopathology, social and interpersonal functioning, subjective wellbeing, quality of life, adverse effects, and physical health.

If researchers or clinicians are interested in broader symptomatology, other versions of PANSS can be used, such as the 8-item version defined by the Andreasen et al criteria, 8 the item version suggested by Levine et al 3 consisting of the 7 positive symptom items and the 7 negative symptom items , or the full PANSS In such cases, it will be relevant to also administer rating scales specifically addressing these symptom domains, such as the Calgary Depression Rating Scale 20 or the Hamilton Anxiety Rating Scale.

That the same information with similar psychometric and clinical validity can be obtained from a much shorter interview is of course a prerequisite for the utility of PANSS Therefore, we plan to subject it to thorough clinical and psychometric validation in research and clinical settings in different countries 23 in the near future. In summary, studies of PANSS-6 so far suggest that this brief scale may represent an advance in clinical trials methodology relating to antipsychotic efficacy.

We also believe that PANSS-6 can orient clinicians to a measurement-based assessment of core psychopathology to evaluate treatment effects, success with core symptom remission, warning of impending relapse, etc. Indeed, it seems that PANSS-6 has the potential to become a useful tool for feasible measurement-based care approaches in schizophrenia.

Measurement-based care has already demonstrated its value in major depressive disorder, 24—32 but has been tested in schizophrenia to a much lesser extent. This work was supported by the Lundbeck Foundation R— to S. Schizophr Bull. Google Scholar. Leucht S. Measurements of response, remission, and recovery in schizophrenia and examples for their clinical application. J Clin Psychiatry. Recommendations to improve the positive and negative syndrome scale PANSS based on item response theory.

Psychiatry Res. Bech P. Clinical Psychometrics. Oxford, UK : Wiley-Blackwell ; Google Preview. BMC Psychiatry. Fleischhacker WW. The usefulness of rating scales in patients with schizophrenia. Acta Psychiatr Scand. PANSS a brief rating scale for the measurement of severity in schizophrenia.

Remission in schizophrenia: proposed criteria and rationale for consensus. Am J Psychiatry. Controlled, dose-response study of sertindole and haloperidol in the treatment of schizophrenia. Sertindole Study Group. A randomized, controlled, dose-ranging trial of sertindole in patients with schizophrenia. Psychopharmacology Berl. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med. American Psychiatric Association.

Diagnostic and Statistical Manual of Mental Disorders. Version 5. Rating scales for affective disorders: their validity and consistency. Acta Psychiatr Scand Suppl.

The relationship between negative symptoms of schizophrenia and extrapyramidal side effects with haloperidol and olanzapine. Psychopharmacol Bull. World Health Organization. Diagnostic Criteria for Research. Geneva : WHO ; Assessing depression in schizophrenia: The Calgary depression scale. Br J Psychiatry Suppl. Hamilton M. The assessment of anxiety states by rating. Br J Med Psychol. Association of Positive and Negative Syndrome Scale short forms with global functioning and quality of life.

Clin Schizophr Relat Psychoses. Clinical results for patients with major depressive disorder in the Texas Medication Algorithm Project.

Arch Gen Psychiatry. Khan, A. J Addict Res Ther 8: Maust, D. Psychiatric rating scales. Opler, L. Reducing guesswork in schizophrenia treatment: PANSS can target and gauge therapy, predict outcomes in clinical practice.



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